Depolarizing Agent that blocks the neuromuscular response. Functions as a rapid onset, short duration muscle relaxant during surgery. Binds to acetylcholine receptors to produce a prolonged action potential by keeping sodium channels open. Degraded by plasma cholinesterase in the plasma membrane. Block is unaffec ted or increased by anticholinesterase drugs. **SIDE EFFECTS: bradycardia, muscle spasms, cardiac arrythmeias, elevated intraocular pressure, malignant hypothermia, electrolyte imbalance
Mutation in sarcoplasmic reticulum, causing too much calcium release. Leads to elevated body temperature, muscle spasms, “tuna burn”. Must be pre-treated with SR calcium blocker that target the ryanodine receptors.