excessive dietary iron absorption and iron accumulation in liver and other organs

HFE Hemochromatosis
– Cirrhosis
– hepatocellular carcinoma
– diabetes
– cardiomyopathy and heart failure
– hypogonadism
– thyroid and other endocrine dysfunction
– arthropathy
– skin pigmentation
= are the most important clinical complications

HFE Hemochromatosis
due to *HFE gene*, homozygosity for HFE *C282Y* is present in most pts. Iron overload is *delayed to adulthood due to protective effect of increased iron requests in kids that counterbalance the effect of this genotype*